理论研究表明,钙通道阻滞剂都具有抗惊厥作用。这一点通过近年来的动物实验(癫痫模型)和临床观察,已逐步得到证实。其中,具有镇静作用的氟苯桂嗪(Flu-narizine)已获准在临床上应用。异搏定和硫氮草酮(Diltiazem)因抑制卡马西平的生物转化,产生神经毒性副作用,故在抗癫痫治疗上应用甚少。本文作者用心痛定(Nifedipine)辅助治疗12例难治性癫痫(Intractable epilepsy),收到了显著的效果。12例病人中,男8例,女4例,年龄20～58岁,其癫痫病史为2～42年(有10例为复杂性部分发作患者)。患者在来癫痫病门诊前,都已服药治疗一年以上。其中7例单独服用卡马西平,2例卡马西平合用丙戊酸钠或苯巴比妥,2例单用苯妥因钠,1例用丙戊酸钠合并苯巴比妥。病 Theoretical studies have shown that calcium channel blockers have anticonvulsant effect. This has been gradually confirmed by animal experiments (epilepsy model) and clinical observation in recent years. Among them, the sedating action of flubenzuron (Flu-narizine) has been approved for clinical use. Verapamil and diltiazem (diltiazem) due to inhibition of carbamazepine biotransformation, resulting in neurotoxic side effects, it is rarely used in the anti-epileptic treatment. The authors received 12 treatments of Intractable epilepsy with Nifedipine and received significant results. Twelve patients, 8 males and 4 females, aged 20 to 58 years old, the history of epilepsy for 2 to 42 years (10 patients with complex partial seizures). Patients before taking epilepsy clinic, have been taking medicine for more than a year. Seven of them took carbamazepine alone, two of them took sodium valproate or phenobarbital, two of them used phenytoin alone, and one of them combined phenobarbital with phenobarbital. disease