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目的:介绍复方苯丁胺/托吡酯缓释剂的研究进展,为其临床应用提供参考。方法:查阅近年来国外相关文献,对复方苯丁胺/托吡酯缓释剂的药理机制、药动学、临床研究、不良反应、禁忌证、用法与剂量等方面的研究进展进行归纳和总结。结果:复方苯丁胺/托吡酯缓释剂用于体质量指数(BMI)>30 kg/m2或者BMI>27 kg/m2伴高血压、高血脂、糖尿病、腹部肥胖患者的辅助减肥,体质量减轻率较大且作用维持较好,服药期间可改善血糖控制。结论:复方苯丁胺/托吡酯缓释剂为安全有效的减肥辅助制剂,有必要进一步进行其在儿童和青少年中的临床试验。
Objective: To introduce the research progress of compound phentermine / topiramate sustained-release agent and provide reference for its clinical application. Methods: To review and summarize the research progress of pharmacological mechanisms, pharmacokinetics, clinical studies, adverse reactions, contraindications, usage and dosage of the compound phentermine / topiramate sustained release agent in reference to relevant literature in recent years. RESULTS: Compound phentermine / topiramate sustained-release was used to assist weight loss and weight loss in patients with hypertension, hyperlipidemia, diabetes and abdominal obesity with a body mass index (BMI)> 30 kg / m2 or BMI> 27 kg / Larger rate and better maintenance, medication can improve glycemic control. CONCLUSIONS: Compound phentermine / topiramate sustained release is a safe and effective weight-loss supplement and it is necessary to further carry out its clinical trials in children and adolescents.