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目的 探讨先天畸形胎儿肺部病变特征及畸形与肺部感染的病因。方法 用苏木精 伊红染色观察肺部病变 ,用金葡菌及其L型免疫组化染色检测细菌及其抗原 ,用PCR技术检测肺炎组织中的金葡菌DNA。结果 2 1例先天畸形胎儿标本中 11例 (5 2 4 % )患有间质性肺炎 ,其中 4例 (19 0 % )PCR检测到金葡菌DNA ,5例 (2 3 8% )检测到金葡菌L型抗原 ,3例 (14 3% )免疫组化和PCR检测同时阳性。结论 金葡菌L型感染与胎儿畸形及其肺部感染可能有关。
Objective To investigate the characteristics of fetal pulmonary lesions and the causes of deformities and pulmonary infections in congenital malformations. Methods Pulmonary lesions were observed by hematoxylin and eosin staining. Staphylococcus aureus and its L-type immunohistochemistry were used to detect the bacteria and their antigens. PCR was used to detect S. aureus DNA in pneumonia tissues. Results 11 (52.4%) fetuses with congenital anomalies had interstitial pneumonia, of which 4 (190%) detected S. aureus DNA by PCR and 5 (23.8%) detected by PCR Staphylococcus aureus L antigen, 3 cases (14 3%) immunohistochemistry and PCR test were positive at the same time. Conclusion Staphylococcus aureus L-type infection may be related to fetal malformation and pulmonary infection.