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利用血卟啉光敏作用杀伤肿瘤细胞治疗癌症已引起人们的广泛注意,但其作用机理并不十分清楚。一般认为血卟啉光敏作用导致细胞坏死是因为产生了具有强烈氧化作用的细胞毒素——单线态氧(~1O_2)。也有人认为光照血卟啉产生血卟啉自由基和超氧阴离子自由基。单线态氧和超氧阴离子可能诱导产生羟基自由基。自旋捕集(Spin Trapping)技术为鉴别和
The use of hematoporphyrin photosensitization to kill tumor cells has attracted widespread attention in the treatment of cancer, but its mechanism of action is not well understood. It is generally believed that the photoactivation of hematoporphyrin results in cell necrosis due to the production of a singlet oxygen (~ 10 O2), which has a strong oxidative effect. Some people think that hematoporphyrin photoproduction hematoporphyrin free radicals and superoxide anion free radicals. Singlet oxygen and superoxide anion may induce hydroxyl radicals. Spin Trapping technology to identify and