1991年8月,美国国家科学院医学研究所发表了本报告,包括18种与百白玻(DTP)疫苗有关的不良反应和4种与目前使用的风疹疫苗菌株-RA27/3有关的不良反应。该所花了20个月复习多方面的资料,包括许多系列的病例及个案报告,其中有发表的或尚未发表的,有流行病学研究、动物实验及其它实验室研究。结果发现DTP疫苗可引起过敏、急性脑病及休克或类休克状态。DTP疫苗内的百日咳疫苗成分还可引起持续的极度哭闹不安。而风疹疫苗则可引起成人女性的急、慢性关节炎。但是,DTP疫苗与婴儿抽动症、脑电节律异常、Reye综合征及 In August 1991, the Institute of Medicine of the National Academy of Sciences published this report, which included 18 adverse reactions related to the DTP vaccine and 4 adverse reactions associated with the currently used rubella vaccine strain RA27 / 3. It took 20 months to review a wide range of information, including many series of case and case reports, including published or unpublished epidemiological studies, animal experiments and other laboratory studies. The results showed that DTP vaccine can cause allergies, acute encephalopathy and shock or shock-like state. The pertussis vaccine component within the DTP vaccine can also cause sustained extreme crying disturbances. The rubella vaccine can cause acute and chronic arthritis in adult women. However, the DTP vaccine and twitch syndrome, abnormal brain electrical rhythm, Reye syndrome and