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目的探讨慢性肾脏病(CKD)患者的甲状腺功能状态。方法回顾性分析住院CKD患者1113例的临床资料,计算不同甲状腺疾病的患病率,比较不同CKD阶段甲状腺激素水平的差异。结果 CKD5和CKD1期患者的甲状腺功能减退(甲减)的患病率分别为10.3%和6.8%。伴随着肾小球滤过率(GFR)的下降,甲减的患病率增加。GFR与三碘甲状腺原氨酸总量呈正相关(r=0.415,P<0.05)。结论在CKD,尤其是CKD5期患者,甲减及正常甲状腺病态综合征患病率增高。CKD与甲状腺功能关系密切。
Objective To investigate thyroid function in patients with chronic kidney disease (CKD). Methods A retrospective analysis of 1113 cases of hospitalized patients with CKD clinical data to calculate the prevalence of different thyroid diseases, thyroid hormone levels at different stages of CKD were compared. Results The prevalence of hypothyroidism (hypothyroidism) in CKD5 and CKD1 patients was 10.3% and 6.8%, respectively. With a decrease in glomerular filtration rate (GFR), the prevalence of hypothyroidism increases. The GFR was positively correlated with the total triiodothyronine (r = 0.415, P <0.05). Conclusions The prevalence of hypothyroidism and normal thyroid syndrome is increased in patients with CKD, especially CKD5. CKD and thyroid function are closely related.