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近年来临床药师在与医师查房中,常见某些患者血小板减少无法解释,而部分患者发生血小板(Plt)减少前曾使用过肝素,检索相关文献发现肝素会导致血小板减少。肝素是临床最常用的抗凝药之一,成份为硫酸氨基葡聚糖,属酸性粘多糖,多由牛肺或牛肠、猪肠、羊肠中提取,因其最初得自于肝脏故名肝素。20世纪40年代首次用于临床,60多年以来肝素广泛用于抗凝治疗。
In recent years, clinical pharmacists and physicians in the rounds, the common thrombocytopenia in some patients can not be explained, and in some patients before the onset of platelet (Plt) had used heparin, retrieve the relevant literature found that heparin can lead to thrombocytopenia. Heparin is one of the most commonly used anticoagulant drugs in clinical practice. Its composition is aminoglucin sulfate, which is an acidic mucopolysaccharide. It is mostly extracted from bovine lungs or cow intestines, pig intestines and sheep intestines because of its initial derivation from the liver heparin. For the first time in the 1940s for clinical use, heparin is widely used anticoagulant therapy for more than 60 years.