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目的探讨静脉盐酸地尔硫卓对起搏阈值及心内电信号振幅的影响。方法植入心脏起搏器术后1～3天的患者133例,静脉注射盐酸地尔硫卓注射液10 mg,间隔10 min后重复给药10 mg,采取体外程控仪,测定用药前及用药后30,60,120,240 min时的心房、心室起搏阈值及P波、R波振幅。结果用药前及用药后不同时段的心房、心室起搏阈值及P波、R波振幅均无明显变化(P>0.05)。结论静脉注射盐酸地尔硫卓对急性期起搏阈值及心内电信号振幅均无影响。
Objective To investigate the effects of intravenous diltiazem on pacing threshold and amplitude of intracardiac electrical signals. Methods One hundred and thirty-three patients with intracardiac pacemakers 1 to 3 days postoperatively were injected intravenously with 10 mg diltiazem hydrochloride injection 10 min after repeated 10 min intervals. Atrial, ventricular pacing threshold and P wave and R wave amplitudes at 60,120,240 min. Results The atrial and ventricular pacing threshold, P wave amplitude and R wave amplitude before treatment and at different time points after treatment did not change significantly (P> 0.05). Conclusion Intravenous diltiazem hydrochloride has no effect on the pacing threshold and the amplitude of intracardiac electrical signals in acute phase.