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随着对于急性缺血性脑卒中(AIS)病理生理过程的深入了解,临床救治手段有了长足的发展。现已证实在卒中发作后3h内迅速溶栓并恢复缺血半暗带的再灌注有良好的临床疗效。但是由于治疗时间窗窄,且大众缺乏卒中的相关专业知识,目前仅有少数患者能够得到及时救治。大量临床资料验证了AIS患者“时间就是脑组织”的概念,及时的急救措施能够减少脑组织的损伤。脑保护药物的研制将使更多的患者在影像学检查之前,甚至在救护车上即能得到及时有效的治疗,而卒中单元内的多学科综合管理将使所有的AIS患者从中受益。
With the in-depth understanding of the pathophysiology of acute ischemic stroke (AIS), there has been considerable development of clinical approaches to treatment. Has been confirmed within 3h after stroke onset rapid thrombolysis and recovery of ischemic penumbra reperfusion has a good clinical effect. However, due to the narrow time window for treatment and the public lack of related expertise in stroke, only a few patients are able to receive timely treatment. A large number of clinical data validated the concept of “time is brain tissue” in patients with AIS, and prompt first-aid measures can reduce brain tissue damage. The development of brain-protective drugs will enable more patients to receive timely and effective treatment even before an imaging examination, even in ambulances, and the multidisciplinary management of stroke units will benefit all AIS patients.