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目的:探讨人乳头瘤病毒(HPV)检测用于宫颈电环切术(Leep)治疗宫颈上皮内瘤变(CIN)预后评估的年龄组差异。方法:随机抽取21~40岁不同年龄段病例各50例,各组病例均为液基细胞学检测(TCT)异常,高危型HPV感染,组织学检查证实为CIN1~3的妇女实行Leep治疗,治疗后3、6、9、12个月检测HPV DNA,HPV持续感染病例再行组织学病理检查。结果:21~30岁年龄范围内的人群Leep治疗后HPV持续感染率为10.0%(3/30),31~40岁年龄范围内的人群Leep治疗后HPV持续感染率为33.3%(10/30)。21~25岁组治疗后HPV阴转率均高于31~35岁组和36~40岁组,统计学分析有显著性差异(p(0.05)。21~25岁组治疗后HPV阴转率与26~30岁组间无统计学意义(P(0.05),31~35岁组治疗后HPV阴转率与36~40岁组间无统计学意义(P(0.05)。结论:31~40岁高危型HPV持续感染率高,需加强高年龄人群的随访和扩大Leep治疗范围。
OBJECTIVE: To investigate the difference of age groups between the detection of human papillomavirus (HPV) in the prognosis assessment of cervical intraepithelial neoplasia (CIN) by electrocautery. Methods: Fifty cases of 21 ~ 40 years of age were randomly selected. All cases were diagnosed as having liquid-based cytology (TCT) abnormalities and high-risk HPV infection. The patients whose histological examination confirmed CIN1 ~ 3 were treated with Leep, HPV DNA was detected at 3, 6, 9 and 12 months after treatment, and histopathological examination was performed on persistent HPV infection. Results: The persistence rate of HPV infection in Leep group was 10.0% (3/30) among those aged 21-30 years old and 33.3% (10/30) after Leep treatment in the age group of 31-40 years old ). The HPV negative conversion rate of 21 ~ 25 years old group was higher than that of 31 ~ 35 years old group and 36 ~ 40 years old group, the statistical analysis had significant difference (p (0.05) .21 ~ 25 years old group after treatment of HPV negative conversion rate (P (0.05)). There was no significant difference between the negative conversion rate of HPV in the 31-35 years old group and the 36-40 years old group (P <0.05) .Conclusion: High-risk patients with high-risk HPV persistent infection rate, need to strengthen the high-age population follow-up and expand the scope of treatment of Leep.