同化类固醇对去势大鼠和小鼠提肛肌重量和肌糖元含量的影响

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已有的资料指出,给去势大鼠注射同化类固醇的最初几天内,提肛肌内糖元含量明显增加。随后提肛肌开始迅速生长,而肌糖元含量逐渐减少。本文研究了同化类固醇对去势或正常大鼠与小鼠的提肛肌或 LBM 重量和对肌糖元含量的影响。结果表明,去势小鼠 LBM 生长速度与所给同化类固醇作用强度和剂量大小有关,但LBM 糖元含量与肌肉生长速度无平行关系。大鼠和小鼠去势后提肛肌和 LBM 重量明显减轻,但糖元含量并不减少。胰岛素和可的松可引起小鼠 LBM 糖元明显增加,但肌肉重量并未增长。MT 刺激小鼠精囊的生长,但精囊的糖元含量反而下降。给去势大鼠注射 TP 后,提肛肌、胫前肌和股直肌糖元含量均有显著增加,然而三种肌肉重量与对照组比较,唯提肛肌重量有显著增加。此外,TP 虽促进大鼠提肛肌的生长,而体外试验表明,给药动物提肛肌利用葡萄糖的能力与对照动物并无显著不同。以上结果似可说明,同化类固醇促进肌肉生长的作用非继发于肌糖元含量的增加。至少可以说,同化类固醇促进糖的利用不是引起肌肉生长的主要条件。 According to the available data, within the first few days after the administration of anabolic steroids to the castrated rats, the content of glycogen in the levator ani increased significantly. Then mention levator ani muscle began to grow rapidly, while muscle glycogen content gradually reduced. This article studies the effects of anabolic steroids on levator ani or LBM weight and muscle glycogen content in castrated or normal rats and mice. The results showed that the growth rate of LBM in ovariectomized mice was related to the strength and dosage of the given steroid, but there was no parallel relationship between LBM glycogen content and muscle growth rate. After the castration of rats and mice levator ani and LBM significantly reduced weight, but the glycogen content is not reduced. Insulin and cortisone caused a significant increase in mouse LBM glycogen but did not increase muscle mass. MT stimulated the growth of mice seminal vesicle, but the seminal vesicle glycogen content decreased. The content of glycogen in levator ani muscle, tibialis anterior tibialis and rectus abdominis increased significantly after castrated TP in ovariectomized rats. However, compared with the control group, the weight of levator ani muscle increased significantly. In addition, TP promoted the development of levator ani muscle in rats, and in vitro tests showed that the ability of administration of glucose to the levator ani muscle was not significantly different from that of the control animals. The above results may indicate that the role of assimilation steroids to promote muscle growth is not secondary to the increase in muscle glycogen content. At least it can be said that assimilation of steroids to promote the use of sugar is not the main condition that causes muscle growth.
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