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目的探讨激素替代疗法和常规疗法对绝经后期妇女相关症状改善效果的差异。方法随机数字表法将134例绝经后期的更年期综合征患者分成研究组(A组)和对照组(B组),每组67例。A组予以激素替代疗法,B组予以常规治疗方案。比对两组患者治疗前后一氧化氮及血脂水平变化情况,记录其抑郁评分、骨密度及激素水平变化差异,分析用药不良反应发生情况。结果治疗后,两组患者骨密度、一氧化氮、高密度脂蛋白胆固醇、雌二醇水平均较治疗前显著提升,且总胆固醇、甘油三酯、黄体生成素、卵泡刺激素水平及汉密尔顿抑郁量表评分较治疗前显著降低,差异均有统计学意义(P<0.05);其中A组各指标变化幅度均大于B组(P<0.05)。两组患者用药后不良反应发生率比较差异无统计学意义(P>0.05)。结论激素替代疗法对改善绝经后期妇女骨密度状态,调节其激素水平等具有积极意义。
Objective To investigate the differences between hormone replacement therapy and conventional therapy in improving the symptoms of postmenopausal women. Methods A random number table method was used to divide 134 cases of menopausal menopausal syndrome into study group (group A) and control group (group B), with 67 cases in each group. A group of hormone replacement therapy, B group to conventional treatment. The changes of nitric oxide and blood lipid levels before and after treatment were compared between the two groups. The difference of depression score, bone mineral density and hormone level were recorded, and the incidence of adverse drug reactions was analyzed. Results After treatment, the bone mineral density, nitric oxide, high density lipoprotein cholesterol, and estradiol levels were significantly increased in both groups compared with those before treatment, and total cholesterol, triglyceride, luteinizing hormone, follicle stimulating hormone and Hamilton depression The scale score was significantly lower than that before treatment, the difference was statistically significant (P <0.05). The change range of each index in group A was greater than that in group B (P <0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P> 0.05). Conclusion Hormone replacement therapy can improve bone mineral density and regulate hormone levels in postmenopausal women.