小儿时期的结缔组织病,较常见的有风湿热、类风湿性关节炎(包括变应性亚败血症)、过敏性紫癜、全身性红斑狼疮等。此类疾病的发生原因,虽尚未完全阐明,但多数认为是一种自身免疫性疾病。其主要病变为全身结缔组织的炎症、增生和变性,受损的血管壁部分坏死,并常有“纤维样物质”沉着。由于全身各部均有结缔组织分布,所以在疾 Pediatric connective tissue disease, the more common rheumatic fever, rheumatoid arthritis (including allergic sepsis), allergic purpura, systemic lupus erythematosus and so on. The cause of such diseases, although not yet fully understood, but most are considered an autoimmune disease. The main lesion is the inflammation, proliferation and degeneration of the connective tissue of the body, the partial necrosis of the damaged blood vessel wall, and the frequent presence of “fibrous material”. Due to the distribution of connective tissue throughout the body, so in the disease