论文部分内容阅读
生长激素积放抑制因子(Somatostatin,Somatotropin Release Inhibiting Factor,SRIF)这种从羊下丘脑分离出来并由Guillemin及其同事合成的14肽,起初被认为是对生长激素分泌的一种特殊抑制物。随后不久就发现,这种因子也存在于中枢神经系统的其它部位以及胰腺的D细胞、胃和上段肠管。进一步的研究证明,SRIF还抑制许多其它激素(如胰岛素、胰高血糖素、促甲状腺激素、胰多肽、抑胃肽、血管活性肠肽、肠促胰酶素、肠促胰液肽、胃动素和胃泌素)的分泌,而且还影响外分泌和胃肠道的其它功能。SRIF在活体内半衰期极短(不到一分钟),以及迄今未能在除垂
Somatostatin (Somatotropin Release Inhibiting Factor, SRIF) This 14 peptide, isolated from the hypothalamus of the sheep and synthesized by Guillemin and coworkers, was originally thought to be a specific inhibitor of growth hormone secretion. Shortly thereafter it was discovered that this factor also exists in other parts of the central nervous system as well as in the pancreatic D cells, stomach and upper intestine. Further studies demonstrated that SRIF also inhibits many other hormones (such as insulin, glucagon, thyroid stimulating hormone, pancreatic polypeptide, gastric inhibitory peptide, vasoactive intestinal peptide, augmentin, incretin peptide, motilin And gastrin) secretion, but also affect the exocrine and other gastrointestinal functions. SRIF has a very short half-life (less than a minute) in vivo and has so far failed to cure