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目的探讨Ⅰ，Ⅱ期非霍奇金淋巴瘤（ｎｏｎ－Ｈｏｄｇｋｉｎ＇ｓｌｙｍｐｈｏｍａ，ＮＨＬ）综合治疗的有效方法。材料与方法１９８７年１月～１９８９年１２月收治ＮＨＬ１５２例，分别采用单纯放疗、放疗＋化疗、化疗＋放疗＋化疗、化疗＋放疗和单纯化疗治疗。结果Ⅰ期ＮＨＬ分别采用单纯放疗和放、化综合治疗者，其３，５，７年生存率与复发率相近。而Ⅰ期仅有结内受累者，其３，５，７年生存率单纯放疗组分别为１００．０％，１００．０％，８８．９％，放、化综合治疗组分别为８８．２％，８２．４％，５２．９％，单放组生存率较高，而复发率两组相近；Ⅱ期ＮＨＬ，放、化综合治疗组３，５，７年生存率较单纯放疗组稍高，复发率两组相近，其中高度恶性病例，化疗＋放疗＋化疗组３，５，７年生存率分别为７３．３％，７３．３％，６０．０％，较放疗＋化疗、化疗＋放疗组均高，而复发率较低。结论（１）Ⅰ期ＮＨＬ仅有结内受累者可考虑用单纯放疗。（２）Ⅱ期高度恶性ＮＨＬ推荐化疗＋放疗＋化疗方法。
Objective To explore the effective methods for comprehensive treatment of stage I and II non-Hodgkin’s lymphoma (NHL). Materials and Methods From January 1987 to December 1989, 152 NHL patients were treated with radiotherapy alone, radiotherapy + chemotherapy, chemotherapy + radiotherapy + chemotherapy, chemotherapy + radiotherapy and chemotherapy alone. Results The patients with stage I NHL were treated with radiotherapy alone, combined with radiotherapy and chemotherapy, and their 3, 5, and 7-year survival rates were similar to the recurrence rate. For patients with stage I who had only intra-articular involvement, the 3,5, and 7-year survival rates for the radiotherapy alone group were 100.0%, 100.0%, and 88.9%, respectively. The radiotherapy and chemotherapy comprehensive treatment groups were 88.2% respectively. %, 82.4%, 52.9%, the survival rate in the radiotherapy group was higher, and the recurrence rate was similar in the two groups; the 3, 5, and 7-year survival rates in the stage II NHL, radiotherapy and chemotherapy combined therapy group were slightly lower than those in the radiotherapy group alone. The rates of recurrence and high recurrence were similar in the two groups. Among them, the high-malignant cases, the 3, 5, and 7-year survival rates of the chemotherapy+radiotherapy+chemotherapy group were 73.3%, 73.3%, and 60.0%, respectively. Compared with radiotherapy+chemotherapy and chemotherapy + The radiotherapy group was high and the recurrence rate was low. Conclusions (1) Patients with stage I NHL who have only intra-articular involvement may consider using radiotherapy alone. (2) Stage II high-grade NHL recommended chemotherapy + radiotherapy + chemotherapy.