论文部分内容阅读
目的研究不同剂量的双环醇片治疗慢性乙型肝炎(cHB)的疗效和安全性。方法随机选择139例 CHB 患者分2组接受治疗,口服双环醇片150mg/d(治疗组)或75mg/d(对照组),观察连续用药24周后的疗效和安全性。结果 2组血清氨基转移酶均得到明显下降,且治疗组更为明显(P<0.05);治疗24周后治疗组与对照组 HBeAg 阴转率分别为36.1%和20.9%(P<0.05),均未发生明显的不良反应。结论双环醇片150mg/d 治疗 CHB 在降低血清氨基转移酶及 HBeAg 阴转方面优于75mg/d,安全性好。
Objective To study the efficacy and safety of different doses of bicyclol tablets in the treatment of chronic hepatitis B (cHB). Methods A total of 139 patients with CHB were randomly divided into 2 groups treated with oral bicyclol 150 mg / d (treatment group) or 75 mg / d (control group), and the curative effect and safety of 24 consecutive weeks were observed. Results The levels of serum aminotransferase in both groups were significantly decreased (P <0.05), and the negative conversion rates of HBeAg in treatment group and control group were 36.1% and 20.9% (P <0.05) after 24 weeks of treatment, respectively. No obvious adverse reactions occurred. Conclusion Bicyclol 150 mg / d is better than 75 mg / d in lowering serum aminotransferase and HBeAg negative conversion.