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作者将自身和外源性多肽及其来源的蛋白与4型肺炎球菌( Pn)荚膜多糖( PS4 )结合来诱导抗Pn的T细胞应答。载体分别是自身热休克蛋白6 0 ( HSP6 0 )及其p4 58m片段和外源性免疫蛋白破伤风类毒素( TT)及其T细胞表位肽p30。采用不同品系雌性小鼠( BAL B/ c、BALB/ k、BAL B/ b、C57
The authors induced an anti-Pn T-cell response by binding themselves and exogenous polypeptides and proteins of their origin to Pn capsular polysaccharide (PS4). The vectors were self-heat shock protein 60 (HSP60) and its p4 58m fragment, and the exogenous immunotoxin tetanus toxoid (TT) and its T cell epitope peptide p30. Different strains of female mice (BAL B / c, BALB / k, BAL B / b, C57