用人参多糖致敏家兔后,采集血清,用体外细胞毒试验证明;人参多糖致敏血清对人和鼠的肿瘤细胞株有不同程度的杀伤作用。从血清中提取的有细胞毒活性的粗提液经局部和静脉注入荷瘤动物体内.24h后,肉眼可见肿瘤局部和中心有坏死褐色变区域;镜下可见:肿瘤组织出现出血、坏死,细胞核浓缩、破碎、溶解、消失等。通过系统实验结果综合分析,认为人参多糖具有一定的抗肿瘤活性,其机制可能是人参多糖诱生了肿瘤坏死因子。 After sensitization of rabbits with ginseng polysaccharide, serum was collected and proved by in vitro cytotoxicity test; ginseng polysaccharide sensitized serum had different degrees of killing effect on human and mouse tumor cell lines. The crude extracts with cytotoxic activity extracted from serum were injected into the tumor-bearing animals by local and intravenous injection. After 24 hours, the necrotic and brown areas were seen locally and at the center of the tumor. The tumor tissue showed hemorrhage and necrosis. Nucleus Concentrate, crush, dissolve, disappear, etc. Through systematic analysis of the experimental results, it is believed that ginseng polysaccharide has a certain anti-tumor activity, and its mechanism may be that ginseng polysaccharide induces tumor necrosis factor.