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采用免疫组化链菌素亲生物素蛋白－生物素酶标（ＬＳＡＢ）法检测３４例狼疮性肾炎 （ＬＮ）患者肾组织中Ｐ选择素及ＧＰⅡｂ／Ⅲａ表达水平。结果表明两者在ＬＮ肾组织中表达部位一 致，且在ＩＶ型和Ｖ型肾小球中表达水平均显著高于Ⅱ型和Ⅲ型，而它们在肾小管、间质的表达水 平与小管间质病变程度密切相关。提示肾组织中Ｐ选择素及ＧＰⅡｂ／Ⅲａ表达水平可能成为判断 ＬＮ严重程度及预后的指标。
The expression of P-selectin and GPⅡb / Ⅲa in renal tissues of 34 patients with lupus nephritis (LN) was detected by streptavidin-biotin-streptavidin-biotin streptavidin-labeling method The results showed that both of them were consistent in the expression of LN in renal tissues, and the expression levels in type IV and type V glomeruli were significantly higher than those in type II and type III. However, their expression levels in tubulointerstitial and interstitial tubules Quality of disease is closely related to the degree. It suggests that the expression of P-selectin and GPⅡb / Ⅲa in renal tissue may be an index to judge the severity and prognosis of LN.