论文部分内容阅读
目的:研究不同剂量的咪唑安定用于纤维胃镜检查的镇静作用及对呼吸和循环的影响。方法:选择104例纤维胃镜检查的患者(ASA Ⅰ～Ⅱ级),随机分为4组,N组为不用药的对照组,MS、M、D组为用药组,分别静脉注射咪唑安定0.07mg·kg~(-1)、0.05mg·kg~(-1)和安定10mg,观察镇静分级、术中症状及记忆缺失、心率、血压和血气的变化。结果:与对照组相比,用药组对胃镜检查的耐受程度明显提高(P<0.05),咪唑安定0.07mg·kg~(-1)组镇静程度、记忆缺失程度和清醒时间明显优于安定组(P<0.05),用药各组MAP在用药后1分钟下降,但无临床意义,血气分析均在正常范围。结论:咪唑安定0.07mg·kg~(-1)作为胃镜检查中镇静用药是安全有效的。
Objective: To study the sedative effects of different doses of midazolam for gastroscopy and their effects on respiration and circulation. Methods: One hundred and four patients (ASA Ⅰ ~ Ⅱ grade) underwent gastroscopy were divided into 4 groups randomly. N group was control group without medication, and MS, M and D groups were treated with midazolam 0.07mg · Kg ~ (-1), 0.05mg · kg ~ (-1) and 10mg diazepam. The sedation and grading, intraoperative symptoms and memory loss, heart rate, blood pressure and blood gas were observed. Results: Compared with the control group, the tolerance to gastroscopy in the treatment group was significantly improved (P <0.05). The sedation, memory loss and wakefulness in the 0.07 mg · kg -1 group of midazolam group were significantly better than those of the stable group Group (P <0.05). MAP in each group decreased in 1 minute after administration, but no clinical significance was found. Blood gas analysis was in the normal range. Conclusion: Midazolam 0.07 mg · kg ~ (-1) is safe and effective for sedation in gastroscopy.