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大约25%的新生儿重症监护病房(NICU)患儿因不同情况,如充血性心衰、液体超负荷、早产儿呼吸窘迫综合症(RDS)或支气管肺发育不良(BPD)等接受反复的利尿剂,早期发现并预防继发性电解质失衡对临床结局非常重要。本文研究了接受速尿和利尿酸治疗的新生儿和婴儿电解质和酸碱异常的发病率及危险因素。1977～1982年在蒙特利尔儿童医院NICU 住院的1200名患儿中有142名接受了319次速尿治疗(1次治疗为给与1剂药或多剂药但两剂间隔<3天),其中24次与利尿酸合用。患儿平均出生体重1794.3±1003.3g,胎龄32.1±4.8周,入NICU 时年龄2.42±0.49天。
Approximately 25% of neonatal NICU patients receive repeated diuresis due to different conditions such as congestive heart failure, fluid overload, premature infants with respiratory distress syndrome (RDS) or bronchopulmonary dysplasia (BPD) Agents, early detection and prevention of secondary electrolyte imbalance is clinically important. This article studies the incidence and risk factors for electrolyte and acid-base abnormalities in neonates and infants treated with furosemide and uric acid. Of the 1,200 children hospitalized in the NICU of Montreal Children’s Hospital from 1977 to 1982, 314 received furosemide treatment (1 treatment with one or more doses but with two doses less than 3 days apart), of which 24 times combined with diuretic. Children with an average birth weight of 1794.3 ± 1003.3g, gestational age 32.1 ± 4.8 weeks, age 2.42 ± 0.49 days into the NICU.