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目的:观察柴芍和胃颗粒对甲巯咪唑致慢性浅表性胃炎小鼠的影响。方法:甲巯咪唑ig 28 d建立慢性浅表性胃炎小鼠模型,给药3周后HE染色,对小鼠胃黏膜做病理学检测;采用比色法检测胃黏膜PGE2、磷脂、氨基己糖含量;采用放免法检测血清胃泌素含量。结果:与模型组相比,柴芍和胃给药组能减轻甲巯咪唑致慢性浅表性胃炎小鼠胃黏膜的病理性损伤,增加黏膜氨基己糖含量,提高黏膜磷脂、PGE2水平,降低血清胃泌素水平,以2 g.kg-1剂量组作用更为明显。结论:柴芍和胃可以明显减轻甲巯咪唑致慢性浅表性胃炎小鼠胃黏膜的炎症和损伤,保护胃黏膜,其机制可能与增加小鼠胃黏膜氨基己糖含量,提高黏膜磷脂、PGE2的水平,降低血清胃泌素水平有关。
Objective: To observe the effects of Chai Shao Hewei Granule on mice with chronic superficial gastritis induced by methimazole. Methods: A mouse model of chronic superficial gastritis was established on the 28th day after methimazole treatment. HE staining was performed 3 weeks after the administration of the drug. The gastric mucosa of the mice was examined by pathology. The contents of PGE2, phospholipid, Content; using radioimmunoassay serum gastrin levels. Results: Compared with the model group, Chaishao and stomach administration groups could alleviate the pathological injury of gastric mucosa in mice with chronic superficial gastritis caused by methimazole, increase the content of aminocaproate in the mucosa, and increase the mucosal phospholipid and PGE2 levels Serum gastrin levels to 2 g.kg-1 dose group more obvious effect. Conclusion: Chaihao and stomach can significantly reduce the inflammation and injury of gastric mucosa induced by methimazole in mice with chronic superficial gastritis and protect the gastric mucosa. The mechanism may be related to the increase of the content of aminohexose in gastric mucosa, the increase of mucosal phospholipid, PGE2 Level, lower serum gastrin levels.