论文部分内容阅读
目的研究中国汉族人群核苷酸切除修复基因XPAA23G多态与肺癌遗传易感性的关系。方法采用病例-对照研究方法,以PCR-RFLP技术分析了310例经组织学确诊的肺癌病例和341例按年龄、性别频数配对的非肿瘤医院对照XPA基因A23G多态.比较不同基因型与肺癌风险的关系,并探讨不同环境因素在其中所起的影响。结果XPA基因A23G多态三种基因型在肺癌病人和对照间的分布差异具有显著性(x2=6.607,P=0.037)。与携带XPA23AA基因型者相比较,携带至少一个23G等位基因(即23GG和23AG基因型)的个体肺癌风险降低34%(校正OR:0.66,95%CI=0.44-0.98)。分层分析显示,此保护作用在肿瘤家族史阳性者中尤为明显,校正OR为0.31(95%CI=0.13-0.76)。结论XPAA23G多态性可能与中国汉族人群肺癌遗传易感性有关,这一相关性有待进一步的体内和体外功能学研究来证实。
Objective To investigate the relationship between polymorphism of nucleotide excision repair gene XPAA23G and susceptibility to lung cancer in Chinese Han population. Methods A case-control study was used to analyze XPA gene A23G polymorphism in 310 cases of histologically diagnosed lung cancer and 341 cases of non-tumor hospital matched by age and sex frequency using PCR-RFLP.Comparison of different genotypes with lung cancer Risk, and explore the impact of different environmental factors in which. Results The distribution of XPA gene A23G polymorphism among lung cancer patients and controls was significant (x2 = 6.607, P = 0.037). Individuals carrying at least one 23G allele (ie, the 23GG and 23AG genotypes) had a 34% reduction in the risk of lung cancer (adjusted OR: 0.66, 95% CI = 0.44-0.98) compared to those carrying the XPA23AA genotype. Hierarchical analysis showed that this protective effect was particularly evident in patients with positive family history of cancer, with a corrected OR of 0.31 (95% CI = 0.13-0.76). Conclusions XPAA23G polymorphism may be related to genetic susceptibility to lung cancer in Chinese Han population. This correlation needs to be confirmed by further in vitro and in vivo functional studies.