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本文比较了肾移植病人用环孢素和强的松与用硫唑嘌呤和强的松作为免疫抑制剂的肾血管阻力。用~(131)碘—邻碘马尿酸钠肾扫描测定有效肾血浆流量(ERPF),测定ERPF当天记录平均动脉压(1/3收缩压+舒张压),用(平均动脉压/ERPF)×100算出肾血管阻力。一组前瞻性研究中,14名接受尸体肾移植后肾功能良好的患者(Scr<177μmol/L)由于经济原因在移植后244±22天或平均0.7年将环孢素改为硫唑嘌吟,换药前的环孢素用量为395mg±30mg/日,其全血浓度为519±55ng/ml。换药后不到一个月ERPF由236±16ml/min增加到322±21ml/
This article compares renal vascular resistance with cyclosporine and prednisone in renal transplant patients and with immunosuppressants with azathioprine and prednisone. The effective renal plasma flow (ERPF) was measured by ~ (131) iodine-o-iodo-hippuric acid sodium scintigraphy. The mean arterial pressure (1/3 systolic pressure + diastolic pressure) 100 calculated renal vascular resistance. In a prospective series of 14 patients with good renal function following cadaver kidney transplantation (Scr <177 μmol / L), cyclosporine was switched to azathioprine for economic reasons at 244 ± 22 days after transplantation or an average of 0.7 years , Before cyclosporine dosage of 395mg ± 30mg / day, the whole blood concentration of 519 ± 55ng / ml. Less than one month after dressing change, ERPF increased from 236 ± 16 ml / min to 322 ± 21 ml /