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虽然CDIa 分子和HLA Ⅰ类分子的有些特征差异较大,如HLAⅠ类分子几乎存在于机体所有有核细胞的表面,而成熟外周血T 细胞则无CDla 分子;HLA Ⅰ类分子往往是多态性的,而CDla 分子则为单态性;HLA Ⅰ类分子定位在人染色体6,而CDla分子则由人染色体Ⅰ编码.但是,HLA Ⅰ类分子和CDIa 重链均能与数种细胞表面分子相关并形成分子间复合物例如,HLAⅠ类分子能和多肽激素或生长因子的受体相互作用,HLA Ⅰ类分子能和某些白血病T 细胞上的T 细胞受体样物质形成分子间复合物,同样,CDla 重链则和CD 8分子共价
Although some features of CDIa molecules and HLA class I molecules are quite different, such as HLA class I molecules almost exist on the surface of all the nucleated cells in the body, while mature peripheral blood T cells have no CDla molecules; HLA class I molecules are often polymorphic While the CDla molecule is monomorphic; HLA class I molecules are located on human chromosome 6, whereas CDla molecules are encoded on human chromosome I. However, HLA class I molecules and CDIa heavy chains are all associated with several cell surface molecules For example, an HLA class I molecule can interact with a polypeptide hormone or a growth factor receptor. HLA class I molecules can form intermolecular complexes with T cell receptor-like substances on certain leukemia T cells. Similarly, , The CDla heavy chain is covalently attached to the CD8 molecule