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目的:对补肾健骨滴丸进行小鼠药效学研究,探讨补肾健骨滴丸的补肾助阳机理,为进一步研究开发治疗肾阳虚症新药提供实验依据。方法:采用常规肾阳虚症动物模型,观察低温游泳时间、脏器系数、血浆睾酮含量等指标。结果:补肾健骨滴丸能显著增强肾阳虚症小鼠的耐疲劳能力,增加去势小鼠的附性器官重量,并能提高肾阳虚症小鼠的免疫能力,提高阳虚症大鼠的血浆睾酮的含量。结论:补肾健骨滴丸具有较好的补肾助阳功效。
OBJECTIVE: To study the pharmacodynamics of Bushen Jiangu Dripping Pills in mice and to explore the mechanism of Bushen Jiangu Dripping Pills for tonifying kidney and promoting yang, so as to provide experimental basis for further research and development of new drugs for treatment of kidney-yang deficiency syndrome. Methods: The animal model of kidney-yang deficiency syndrome was used to observe the swimming time, organ coefficient, plasma testosterone content and other indicators. RESULTS: Bushen Jiangu Dripping Pills can significantly enhance the fatigue resistance of mice with kidney-yang deficiency syndrome, increase the weight of the epiglottis in castrated mice, and can improve the immunity of mice with kidney-yang deficiency syndrome, and increase plasma testosterone in rats with yang deficiency syndrome. The content. Conclusion: Bushen Jiangu Dripping Pills have a good effect of tonifying kidney and promoting yang.