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目的检测急性脑梗患者中血浆抗凝血酶III活性(AT-III)、血浆凝血酶原时间(PT)、活化部分凝血酶原时间(APTT)、血浆纤维蛋白(Fg)含量,探讨其四项指标在急性脑梗患者中的变化及其临床意义。方法选择急性脑梗者94例,对照组65例,采用发色底物方法、凝固法、凝血酶比浊法分别进行检测分析AT、PT、APTT、Fg。结果脑梗患者血浆AT-III活性为84.2±13.9%,对照组为96.9±11.8%,两者比较有显著性差异p<0.05,而PT、APTT、Fg含量无明显差异p>0.05。结论观察血浆AT活性有助于急性脑梗的早期诊断及预后判断。
Objective To detect plasma antithrombin III activity (AT-III), plasma prothrombin time (PT), partial prothrombin time (APTT) and plasma fibrin (Fg) content in patients with acute cerebral infarction Changes and Clinical Significance of Indexes in Patients with Acute Cerebral Infarction. Methods 94 patients with acute cerebral infarction and 65 control subjects were enrolled in the study. AT, PT, APTT and Fg were detected by chromogenic substrate method, coagulation method and thrombin turbidimetry respectively. Results The plasma AT-III activity in patients with cerebral infarction was 84.2 ± 13.9%, while the control group was 96.9 ± 11.8%. There was a significant difference between the two groups (p <0.05), but there was no significant difference in PT, APTT and Fg (p> 0.05). Conclusion The observation of plasma AT activity contributes to the early diagnosis and prognosis of acute cerebral infarction.