疼痛由感觉、情感、认知等多个维度组成。慢性痛常伴有焦虑和抑郁等负性情绪。并且,负性情绪可以加剧疼痛。慢性应激引起生化、生理和心理等一系列的变化,导致情绪紊乱,增加慢性痛发生的风险或加剧慢性痛。但是其中的神经生物学机制尚不清楚。已有研究提示,杏仁核可能在慢性应激调节慢性痛中发挥重要的作用。杏仁核包括很多亚区,其中外侧杏仁核(LA)/基底外侧杏仁核(BLA),以及中央杏仁核(CeA)在情绪和疼痛中发挥重要作用。CeA接受经脊髓-臂旁核(PB)传来的痛觉信息。LA和BLA接受丘脑和 Pain consists of many dimensions such as feeling, emotion, cognition and so on. Chronic pain is often accompanied by negative emotions such as anxiety and depression. And, negative emotions can aggravate pain. Chronic stress causes a series of changes in biochemistry, physiology and psychology, leading to emotional disorders, increasing the risk of chronic pain or aggravating chronic pain. However, the neurobiological mechanisms are not clear. It has been suggested that the amygdala may play an important role in chronic stress-conditioning chronic pain. The amygdala includes a number of subregions, including the lateral almond (LA) / basolateral amygdala (BLA), and central amygdala (CeA) which play important roles in mood and pain. CeA receives pain information from the spinal cord - parabrachial nucleus (PB). LA and BLA receive the thalamus and