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目的研究穿琥宁注射液与临床常用输液的配伍条件。方法选择温度、光照、放置时间、溶媒种类4个影响因素,以穿琥宁含量、配伍液的p H值变化、不溶性微粒数为检测指标,同时考察不同条件下配伍液中穿琥宁有关物质的限度。结果在4 h内,穿琥宁注射液与5%葡萄糖注射液及0.9%氯化钠注射液可配伍使用,但不宜与5%的葡萄糖氯化钠注射液配伍。结论穿琥宁注射液与5%葡萄糖注射液及0.9%氯化钠注射液在4 h内可配伍使用,应尽量避免日光照射与高温环境。
Objective To study the compatibility of Chuanhuning injection and clinical infusion. Methods Four influencing factors of temperature, illumination, storage time and solvent type were selected. The content of chuanhuning, the p H value of compatibility liquid and the number of insoluble particles were taken as the detection indexes. The limits of Chuanhuning related substances in different compatibility were also investigated. Results within 4 h, Chuanhuning injection and 5% glucose injection and 0.9% sodium chloride injection compatibility can be used, but not with 5% glucose and sodium chloride injection compatibility. Conclusion Chuanhuning injection and 5% dextrose injection and 0.9% sodium chloride injection can be used within 4 h, sunlight and high temperature should be avoided as far as possible.