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目的:探讨醒脑静对脑出血急性期患者血清转铁蛋白(Tf)及铁蛋白(Ft)的变化,并观察神经功能改善状况,为评估脑出血急性期治疗提供依据。方法:选择2004年2月—2010年2月医院急性脑出血患者122例,随机分为对照组和治疗组,对照组60例,进行常规治疗,治疗组62例,在对照组基础上应用醒脑静治疗,选取同期健康体检者30例,为正常组。入院后第1、3、7、14、21天检测血清Tf及Ft水平。采用美国国立卫生院神经功能缺损评分标准(NIHSS)在入院第1、7、14、21天对患者进行神经功能缺损程度评分。结果:治疗组和对照组Tf在第1天高于正常组(P1=0.025,P2=0.031);对照组Tf在发病第3天高于正常组(P1=0.014)。治疗组Tf在第3天较对照组显著下降(P=0.034)。治疗组和对照组血清Ft在发病后第7天、14天与正常组比较,差异具有统计学意义(P1=0.018,0.025,0.001,0.038)。对照组Ft在第21天高于正常组(P=0.005);治疗组第7天、第14天血清Ft低于对照组(P1=0.009,P2=0.038)。血量在10~20 m L及≥20 m L时,治疗组血清Tf和Ft均低于对照组,差异具有统计学意义(P1=0.006,0.007;0.021,0.039)。对照组和治疗组第7天、14天、21天NIHSS评分比较,差异有统计学意义(P=0.004,0.002,0.001)。结论:醒脑静注射液可以降低脑出血急性期血清转铁蛋白及铁蛋白水平,改善患者神经缺损程度。
Objective: To investigate the effect of xingnaojing on the changes of serum transferrin (Tf) and ferritin (Ft) in patients with acute cerebral hemorrhage and to observe the improvement of neurological function in order to provide basis for the assessment of acute cerebral hemorrhage. Methods: A total of 122 patients with acute cerebral hemorrhage in our hospital from February 2004 to February 2010 were randomly divided into control group, treatment group and control group. Sixty-two patients in control group were treated with routine treatment Cerebral static treatment, select the same period of 30 healthy physical examination for the normal group. Serum Tf and Ft levels were detected on the 1st, 3rd, 7th, 14th and 21st day after admission. Patients were assessed for neurological deficit by National Institutes of Health neurological deficit score (NIHSS) on days 1,7,14 and 21 of admission. Results: The Tf of the treated group and the control group was higher than that of the normal group on the first day (P = 0.025, P = 0.031). The Tf of the control group was higher than that of the normal group on the third day (P1 = 0.014). The Tf in the treatment group was significantly lower than that in the control group on the third day (P = 0.034). The serum Ft in the treatment group and the control group was statistically significant at the 7th day and the 14th day after onset compared with the normal group (P1 = 0.018,0.025,0.001,0.038). The Ft of the control group was higher than that of the normal group on the 21st day (P = 0.005). The serum Ft of the 7th and 14th days of the treatment group was lower than that of the control group (P1 = 0.009, P2 = 0.038). The serum levels of Tf and Ft in the treatment group were lower than those in the control group at 10-20 m L and ≥20 m L, with statistical significance (P = 0.006, 0.007; 0.021, 0.039). The NIHSS scores of the control group and the treatment group on the 7th, 14th and 21st days were significantly different (P = 0.004,0.002,0.001). Conclusion: Xingnaojing injection can reduce the level of serum transferrin and ferritin in acute stage of cerebral hemorrhage and improve the degree of nerve defect in patients.