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目的：探讨内皮素１（ＥＴ１）在大鼠多脏器功能失常综合征（ＭＯＤＳ）肝衰竭发生机制中的作用。方法：运用组织化学与免疫电镜等方法，观察肝细胞中ＥＴ１及糖原的含量变化。结果：ＭＯＤＳ大鼠肝细胞胞浆ＥＴ１含量明显增多，而糖原含量明显减少。结论：内皮素对肝糖原有分解作用，这是造成ＭＯＤＳ时肝损伤以至影响全身多个脏器损伤的重要因素之一。
Objective: To investigate the role of endothelin 1 (ET1) in the pathogenesis of multiple organ dysfunction syndrome (MODS) in rats with liver failure. Methods: Histochemistry and immunoelectron microscopy were used to observe the changes of ET1 and glycogen in hepatocytes. Results: The content of ET1 in hepatocyte cytoplasm of MODS rats increased obviously, but the content of glycogen obviously decreased. Conclusion: Endothelin has the effect of decomposing hepatic glycogen, which is one of the important factors that cause liver damage in MODS and even affect multiple organ injuries.