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本实验复制了慢性氟中毒大鼠病理模型、对血清碱性磷酸酶(ALP_(ase))活性和钙、磷水平进行了动态观察。结果表明,血清碱性磷酸酶活性在中毒14d内升高,然后下降,在30d时达到谷底,到90d时又恢复到原水平。而血清钙、磷水平在14d以后才开始下降,30d达到谷底,90d恢复到原水平。这一变化规律在饮水含氟(NaF)达0.1mg/mL时最明显。本文用“Mg~(2+)假说”解释了这一变化规律。同时对氟中毒的损伤机制做了初步探讨。
This experiment duplicated the pathological model of chronic fluorosis in rats, and observed the activity of alkaline phosphatase (ALP_ (ase)) and calcium and phosphorus in serum. The results showed that the activity of serum alkaline phosphatase increased within 14d after poisoning, then decreased and reached the trough at 30d, returning to its original level at 90d. Serum calcium and phosphorus levels began to decline after 14d, reaching the trough at 30d and returned to the original level at 90d. This change in the drinking water fluoride (NaF) up to 0.1mg / mL when the most obvious. In this paper, “Mg ~ (2 +) hypothesis” explains this change. At the same time, the damage mechanism of fluorosis was explored.