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本文对４０例糖尿病患者和２０例正常对照的血浆组织型纤溶酶原激活物（ｔ－ＰＡ）、纤溶酶原激活物抑制物（ＰＡＩ）、血浆β血小板球蛋白（β－ＴＧ）、血小板第４因子（ＰＦ４）、血浆血栓素（ＴＸＢ２）、６－酮－前列腺素Ｆ１α（６－酮－ＰＧＦ１α和ＶｏｎＷｉｌｌｅｂｒａｎｄ因子抗原（ＶＷＦ：Ａｇ）进行测定，对糖尿病患者体内血小板反应性增高和血管内皮损伤可能参与肾脏病变的发生所起的作用进行探讨。结果表明：糖尿病息者血浆β－ＴＧ，ＰＦ４，ＶＷＦ：Ａｇ水平增高，ｔ－ＰＡ活性降低，上述改变在无肾病组已存在，并可能参与肾脏病变的发生。血浆ＰＡＩ活性、６－酮－ＰＧＦ１α水平无显著改变；但血浆ＴＸＢ２在肾脏病组降低，尚待进一步探讨。
In this study, 40 patients with diabetes mellitus and 20 normal controls were enrolled in this study. Tissue plasminogen activator (t-PA), plasminogen activator inhibitor (PAI), plasma beta-thromboglobulin Platelet factor 4 (PF4), plasma TXB2, 6-keto-PGF1α (VWF: Ag) were measured in patients with diabetic patients with elevated platelet reactivity and vascular Endothelial injury may play an important role in the pathogenesis of nephrotic syndrome.The results showed that plasma β-TG, PF4 and VWF: Ag levels were increased and t-PA activity was decreased in diabetic subjects. The above changes were found in nephrotic group May be involved in the occurrence of renal disease.Plasma PAI activity, 6-keto-PGF1α levels did not change significantly; however, plasma TXB2 decreased in renal disease group remains to be further explored.