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目的探讨右心室面积变化分数(RVFAC)在肺动脉高压(PH)患者右心功能评价中的价值。方法选择心内科2014年1月至2015年10月收治的PH患者116例(PH组)和健康体检人员30例(对照组),对两组研究对象进行心脏多普勒超声检查,测量肺动脉收缩压(PASP)、右心室Tei指数,计算左心室面积变化分数(RVFAC),并进行血浆N端B型利钠肽前体(NT-pro BNP)水平测定。结果 RVFAC、PASP、Tei指数及血浆NT-pro BNP水平在PH组与对照组间比较及在PH轻度、中度、重度组间比较差异均有统计学意义(P<0.05,P<0.01)。相关性分析显示,RVFAC分别与PASP、血浆NT-pro BNP水平呈负相关(r=-0.652,P<0.05;-0.716,P<0.05),与Tei指数无相关性(r=-0.257,P>0.05),PASP与血浆NT-pro BNP水平呈正相关(r=0.744,P<0.05)。结论 PH患者RVFAC与PASP和NT-pro BNP呈负相关,RVFAC可作为评价PH患者右心功能的有效指标。
Objective To investigate the value of right ventricular area fraction (RVFAC) in evaluating right heart function in patients with pulmonary hypertension (PH). Methods One hundred and sixty-six patients with PH (PH group) and 30 healthy people (control group) were enrolled in the Department of Cardiology from January 2014 to October 2015 in our department. The subjects were examined by Doppler echocardiography, (PASP) and Tei index of right ventricle. The left ventricular area fraction (RVFAC) was calculated and the level of plasma N-terminal pro-brain natriuretic peptide (NT-pro BNP) was measured. Results Compared with PH group and control group, RVFAC, PASP, Tei index and plasma NT-pro BNP levels were significantly different in mild, moderate and severe PH group (P <0.05, P <0.01) . Correlation analysis showed that RVFAC was negatively correlated with PASP and plasma NT-pro BNP level (r = -0.652, P <0.05; -0.716, P <0.05), but not with Tei index (r = -0.257, P > 0.05). There was a positive correlation between PASP and plasma NT-pro BNP levels (r = 0.744, P <0.05). Conclusion RVFAC in patients with PH is negatively correlated with PASP and NT-pro BNP, and RVFAC can be used as a valid indicator to evaluate right heart function in PH patients.