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目的:评价依达拉奉联合丹红注射液对急性脑梗死(ACI)大鼠的疗效和安全性。方法:将SD大鼠随机分为假手术组、模型组、依达拉奉组、丹红注射液组、依达拉奉联合丹红注射液组(联合用药组),采用线栓法制作大鼠左侧大脑中动脉脑缺血(MCAO)模型,除假手术组外,每组按不同时间点(1、3、5、7d)分为4个亚组,观察比较各组大鼠各时相的疗效评价指标(神经功能缺损评分、脑组织梗死体积、脑组织含水量、脑组织形态学改变)及安全性评价指标。结果:与模型组比较,假手术组各项疗效评价指标数值均存在显著差异(P<0.05,P<0.01);与其他用药组比较,模型组各项疗效评价指标及部分安全性评价指标数值均存在显著差异(P<0.05,P<0.01);依达拉奉组与丹红组比较,各项疗效评价指标及安全性指标数值无显著差异;各单药组与联合用药组比较,各项疗效指标数值存在显著性差异(P<0.05),尤以联合用药组第5、7天差异最为显著(P<0.01)。结论:依达拉奉联合丹红注射液治疗ACI疗效优于单用依达拉奉或丹红注射液,且治疗效果可靠安全,并且随治疗时间延长,对脑梗死的改善作用越明显。
Objective: To evaluate the efficacy and safety of edaravone combined with Danhong injection in acute cerebral infarction (ACI) rats. Methods: SD rats were randomly divided into sham-operation group, model group, edaravone group, Danhong injection group, edaravone combined Danhong injection group (combination group) Rats in the left middle cerebral artery occlusion (MCAO) model, except the sham operation group, each group at different time points (1,3,5,7 d) were divided into 4 subgroups, observed and compared each group rats Phase efficacy evaluation index (neurological deficit score, brain infarct volume, brain water content, brain histomorphology) and safety evaluation index. Results: Compared with the model group, there were significant differences in the evaluation indexes of various curative effects between the sham group and the other groups (P <0.05, P <0.01). Compared with the other groups, all the curative effect indexes and some safety evaluation index values There was significant difference (P <0.05, P <0.01); edaravone group and Danhong group, the efficacy evaluation index and safety index value no significant difference; each single drug group compared with the combination group (P <0.05), especially the difference between the 5th and 7th day in the combination group was the most significant (P <0.01). Conclusion: The efficacy of edaravone combined with Danhong injection in treating ACI is better than that of edaravone or Danhong injection alone, and the treatment effect is reliable and safe. With the prolongation of treatment time, the improvement of cerebral infarction is more obvious.