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目的:探讨成都地区体检人群中丙氨酸氨基转移酶(ALT)升高率与其升高的相关因素,为正确分析引起ALT升高的原因提供相关依据。方法:以参与体检的8734名体检人群为研究对象,收集身高、体重、血压、丙氨酸氨基转移酶、空腹血糖、高密度脂蛋白、低密度脂蛋白、总胆固醇、甘油三酯、血清HBsAg、脂肪肝及胆石症等相关资料进行分析。结果:在全部体检人群中,ALT升高率为10.11%,男性ALT升高率为13.70%,女性ALT升高率为6.30%,男性明显高于女性(P<0.001);ALT升高组的年龄均数小于ALT正常组(P<0.001);在ALT升高的受检者中,脂肪肝、高脂血症、肥胖、糖尿病、胆囊结石、饮酒及乙肝等患病率均高于ALT正常组受检者(P<0.05)。结论:脂肪肝、糖脂代谢紊乱及乙肝是体检人员ALT升高的主要原因;男性和低龄也是体检者ALT升高的危险因素。
Objective: To investigate the correlation between the elevated rate of alanine aminotransferase (ALT) and its elevation in the medical examination population in Chengdu, and provide the basis for the correct analysis of the cause of elevated ALT. Methods: A total of 8,734 physical examination population participated in the physical examination. The body weight, blood pressure, alanine aminotransferase, fasting blood glucose, high density lipoprotein, low density lipoprotein, total cholesterol, triglyceride, serum HBsAg , Fatty liver and cholelithiasis and other related data for analysis. Results: The ALT increased rate was 10.11%, the ALT rate was 13.70% in male and 6.30% in female, which was significantly higher in males than in females (P <0.001) (P <0.001). The prevalences of fatty liver, hyperlipidemia, obesity, diabetes mellitus, gallstones, alcohol drinking and hepatitis B among the patients with elevated ALT were higher than those with normal ALT Group subjects (P <0.05). CONCLUSION: Malignant fatty liver, dyslipidemia and hepatitis B are the main causes of elevated ALT in medical staff. Men and young adults are also risk factors for elevated ALT.