服用复方新诺明致口腔、外阴部固定型药疹少见，本文报道2例。[例1]魏某，男，62岁。因“毛囊炎”于1992年3月4日口服复方新诺明2片，每日2次。吹口感周身不适，恶心，头痛，口唇及外阴部麻木、肿痛、瘙痒难忍。有青霉素及磺胺类药过敏史。查体：体温37.7℃，脉搏94次／min，血 Taking cotrimoxazole to the mouth, genital fixed drug eruption is rare, this article reports 2 cases. [Example 1] Wie, male, 62 years old. Due to “folliculitis” on March 4, 1992 oral compound cotinine 2 tablets, 2 times a day. Tone mouth feeling unpleasant, nausea, headache, numbness of the lips and vulva, swelling and pain, itching unbearable. Penicillin and sulfa allergy history. Physical examination: body temperature 37.7 ℃, pulse 94 times / min, blood