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目的 探讨舍曲林联合一般支持性心理治疗对危重烧伤致创伤后应激障碍患者的临床疗效,为临床诊治提供依据.方法 对17例危重烧伤致创伤后应激障碍患者予以舍曲林联合一般支持性心理治疗,观察6个月.于干预前后采用创伤后应激障碍平民版筛查问卷、症状自评量表、焦虑自评量表、抑郁自评量表进行测评分析.结果 本组患者干预后创伤后应激障碍平民版筛查问卷、症状自评量表、焦虑自评量表、抑郁自评量表评分均较干预前显著降低(P<0.05或0.01).相关分析显示,创伤后应激障碍平民版筛查问卷总分干预前与症状自评量表总均分呈显著正相关(P<0.05),干预后与症状自评量表总均分、焦虑自评量表总分、抑郁自评量表总分呈显著正相关(P<0.05或0.01).结论 舍曲林联合一般支持性心理治疗能显著改善危重烧伤致创伤后应激障碍患者的创伤后应激障碍症状及焦虑、抑郁症状,值得临床推广应用.“,”Objective To the efficacy of sertraline plus general supportive psychotherapy (GSP) in post-traumatic stress disorder (PTSD) following severe burn in order to provide basis for clinical diagnosis and treatment. Methods Seventeen patients with PTSD following severe burn were treated with sertraline plus GSP for 6 months. Assessments were performed with the PTSD Checklist-Civilian Version (PCL-C),Symptom Checklist-90 (SCL-90),Self-rating Anxiety Scale (SAS) and Self-rating Depression Scale (SDS) before and after intervention. Results After intervention the PCL-C,SCL-90,SAS and SDS score lowered more significantly compared with pre-intervention (P<0.05 or 0.01). Correlation analysis showed that pre-intervention total PCL-C score was positively related to total SCL-90 score significantly (P<0.05) and post-intervention to total SCL-90,SAS and SDS (P<0.05 or 0.01). Conclusion Sertraline combined with GSP cpuld notably improve the symptoms of PTSD,anxiety and depression and the development of comorbid anxiety and depression should be prevented.