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本实验用甲基胆蒽涂抹小鼠宫颈原位诱发宮颈癌。实驗用甲基胆蒽涂宮頸每周二次,共涂30次(10毫克),然后分三组进行,第一组不加处理,第二組再涂巴豆油七次,第三組进行交配。結果三組91例中共得瘤72例,其中宮頸癌63例,占79.7％。三組比較,加涂巴豆油组之癌贤生数略高。切片观查瘤組織分为5級,各級与不同組別未見有何差別:由阴道涂片上观查,瘤細胞在涂致癌质后9周即有出現,但在切片檢查中以200天上下为最多。此外观查到切片上“(?)”“十”“艹”三級中,阴道涂片检查瘤細胞时,仅部分为阳性,而在“卅”、“(?)”二級中則几全为阳性。本实驗所誘发之宮頸癌很明显现察到由宮颈被盖上皮而来。
In this experiment, methylcholeracene smear mouse cervical in situ induced cervical cancer. The experiment with methylcholanthrene coated cervix twice a week, a total of 30 times (10 mg), and then divided into three groups, the first group without treatment, the second group was re-coated with croton oil seven times, the third group of mating. Results Among the 91 cases in the three groups, there were 72 cases with malignant tumors, of which 63 cases were cervical cancer, accounting for 79.7%. Comparison of three groups, add the croton oil group slightly higher number of cancer Xian students. Slices observed tumor tissue is divided into 5 levels, with different groups at all levels did not see any difference: the vaginal smear on the view, the tumor cells in the coating carcinogenic after 9 weeks that there, but in the biopsy to 200 Mostly up and down the sky. In addition, it was found that in the three stages of “(?)” “Ten” and “艹” on the section, the vaginal smear examination of tumor cells was only partially positive, while in the “卅” and “?” All positive. Cervical cancer induced by this experiment is clearly observed from the cervix covered epithelium.