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近来,Glazer和Bennett指出在患胆盐/胰蛋白酶引起的胰腺炎的狗,静脉血中前列腺素样物质的活性增加。这些狗的腹膜渗出液,经色谱分析显示有高浓度的前列腺素E样物质。由于前列腺素可引起低血压、疼痛和炎症,作者推测它们可能与急性胰腺炎的死亡率有关。消炎痛在体内抑制前列腺素的产生,因而对它在急性实验性胰腺炎中的作用进行了研究。作者在338只雄鼠的胰管内注入3%或5%的牛磺胆酸钠或橄榄油0.6ml,诱发胰腺炎。给动物用胃管导入或肌注消炎痛,并用对照组观察,共分10组实验。结果预先用胃管导入消炎痛处置的动物,5%牛磺胆酸钠引起的胰腺炎的平均存活时间是22.8小时,不用消炎痛的动物的平均存活时间是10.7小时,有明
Recently, Glazer and Bennett pointed out that in dogs with bile salts / trypsin-induced pancreatitis, the activity of prostaglandin-like substances in venous blood is increased. The peritoneal exudate of these dogs showed high concentrations of prostaglandin E-like material after chromatographic analysis. Since prostaglandins cause hypotension, pain and inflammation, the authors speculate that they may be related to mortality from acute pancreatitis. Indomethacin inhibits prostaglandin production in vivo, and therefore its role in acute experimental pancreatitis has been studied. The authors injected 338% of the pancreatic duct of male rats with 3% or 5% sodium taurocholate or olive oil 0.6ml to induce pancreatitis. Animal orgasm for the introduction of or intramuscular injection of indomethacin, and observed with the control group, is divided into 10 groups of experiments. Results The animals in which indomethacin was treated with gastric tube were previously administered. The average survival time of pancreatitis caused by 5% sodium taurocholate was 22.8 hours, that of animals without indomethacin was 10.7 hours,