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Sekiguchi 等发现,脱氧核糖核酸(DNA)和精脒(Spermidine)结合的复合物(简称 DA-51)具有预防照射引起的白细胞减少症的作用。DA-51为 DNA 的磷酸盐与精脒聚胺(NH·(CH_2)_4NH·(CH_2)_3NH_2]结合成分子量约为100,000～500,000的复合物,沉淀常数为>12S;比重1.650～1.700;粘度ηsp/c=3×10~(-4)～6×10~(-4),比旋度 tanα_0=5×10~(-3)～10×10~(-3);吸光度为 E_(max)=2600(?)～2657(?),其结构推测为:
Sekiguchi et al. Found that the combination of deoxyribonucleic acid (DNA) and Spermidine (DA-51) has the effect of preventing irradiation-induced leukopenia. DA-51 is a phosphate complexed with polyamidoamine (NH (CH 2) 4NH · (CH 2) 3NH 2] to form a complex with a molecular weight of about 100,000 to 500,000 with a precipitation constant of> 12S and a specific gravity of 1.650 to 1.700. Viscosity ηsp / c = 3 × 10-4 ~ 6 × 10 -4, specific rotation tanα_0 = 5 × 10-3 ~ 10 × 10 -3, absorbance is E_max ) = 2600 (?) ~ 2657 (?), Its structure is speculated as follows: