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器官移植是目前治疗器官终末期病变的最有效手段,但是移植后的免疫排斥反应明显降低了器官移植的治疗效果。抑制免疫排斥反应是器官移植界的重要课题。丝裂原活化蛋白激酶(mitogen-activated protein kinase,MAPK)信号通路是当今的研究热点,其与免疫细胞的相关性研究已受到广泛关注。p38MAPK作为MAPK家族的重要一员,它不仅参与细胞增殖、分化、凋亡及炎症刺激等病理生理过程,还在免疫系统中起着重要作用。
Organ transplantation is currently the most effective treatment of end-stage organ disease, but the immune rejection after transplantation significantly reduces the therapeutic effect of organ transplantation. Suppression of immune rejection is an important issue in the field of organ transplantation. Mitogen-activated protein kinase (MAPK) signaling pathway is a hot research topic nowadays, and its correlation with immune cells has drawn much attention. As an important member of MAPK family, p38MAPK not only participates in pathophysiological processes such as cell proliferation, differentiation, apoptosis and inflammatory stimuli, but also plays an important role in the immune system.