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用Ⅰ~(131)治疗甲亢,发生晚期甲状腺机能低下者颇多,故有人提出以Ⅰ~(125)代替Ⅰ~(181)治疗甲亢。近年来的某些研究,由于所用Ⅰ~(125)剂量悬殊太大,结果极不统一。据报导,在Ⅰ~(125)治疗后,甲低发生率为9.7～80％,而无效率为15～58％,从而认为Ⅰ~(125)并不比Ⅰ~(131)好。本文报导了5年来用Ⅰ~(125)治疗甲亢的临床经验,研究了有计划地增加Ⅰ~(125)剂量的治疗效果。
With Ⅰ ~ (131) treatment of hyperthyroidism, there is a lot of late hypothyroidism, it was proposed to Ⅰ ~ (125) instead of Ⅰ ~ (181) treatment of hyperthyroidism. In recent years, some studies, due to the use of Ⅰ ~ (125) dose disparity is too large, the results are very uniform. It has been reported that the incidence of hypothyroidism is 9.7 to 80% and the inefficiency is 15 to 58% after I 125 treatment, so that I 125 is not superior to 131 I. This article reports the clinical experience of using I ~ (125) in the treatment of hyperthyroidism over the past five years and investigates the therapeutic effect of a planned increase of I ~ (125) doses.