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The interaction between cucurbit[8]uril(Q[8]) and oroxin B(ORB) was investigated by UV-visible(UV-Vis) spectroscopy,isothermal titration calorimetry(ITC),mass spectrum(MS) and nuclear magnetic resonance(NMR) spectroscopy.The results showed that ORB formed a 2∶1 inclusion complex with Q[8]with a binding constant of 8.266 × 105 L2· mol-2.ORB had good scavenging ability for 2,2-azinobis-(3-ethylbenzthiazoline-6-sulphonate)(ABTS) free radicals(IC50=5.74 μmol/L) and the addition of Q[8]did not significantly affect the antioxidant activity of ORB(IC50=5.76 μmol/L).A phase solubility experiment revealed a 1.86-fold increase in the solubility of ORB when c(Q[8])=100 μmol/L.In vitro drug release experiments showed that the release rate for ORB@Q[8]complex was lower than that of ORB in artificial intestinal juice,and higher than that of ORB in artificial gastric juice.