【摘 要】
：
An efficient method for the synthesis of novel pyrido[3’’,2’’:4’,5’]thieno[3’,2’:2,3]pyrido [4,5:d][1,3]thiazolo[3,2-a]pyrimidine-4-one derivatives(5) h
【机 构】
：
College of Chemistry and Chemical Engineering, Liaoning Key Laboratory of Synthesis and Application
【出 处】
：
Chinese Chemical Letters
论文部分内容阅读
An efficient method for the synthesis of novel pyrido[3’’,2’’:4’,5’]thieno[3’,2’:2,3]pyrido [4,5:d][1,3]thiazolo[3,2-a]pyrimidine-4-one derivatives(5) has been developed using a Pictet–Spengler reaction between 2-(3-aminothieno[2,3-b]pyridin-2-yl)thiazolo[3,2-a] pyrimidin-5-one(3), which could be obtained from the condensation of 7-(chloromethyl)-5H-thiazolo[3,2-a]pyrimidin-5-one(1) with3-cyanopyridine-2-thione(2) via Thorpe–Ziegler isomerization, and aromatic aldehydes under NH_2SO_3 H as catalysis in good yields.
An efficient method for the synthesis of novel pyrido [3 ’’, 2 ": 4 ’, 5’] thieno [3 ’, 2’: 2,3] pyrido [4,5: [3,2-a] pyrimidine-4-one derivatives (5) has been developed using a Pictet-Spengler reaction between 2- (3-aminothieno [2,3- b] pyrimidin-5-one (3), which could be obtained from the condensation of 7- (chloromethyl) -5H-thiazolo [3,2- thione (2) via Thorpe-Ziegler isomerization, and aromatic aldehydes under NH_2SO_3 H as catalysis in good yields.
其他文献
水工混凝土的耐久性直接关系到工程使用寿命、加固费用、效益发挥和运行安全,影响或限制了结构的正常使用功能。针对水工混凝土的常见病害进行分析、提出预防对策。
The dur
Graves病患者外周血白细胞糖皮质激素受体改变及意义
Changes of Glucocorticoid Receptor in Peripheral Blood Leukocytes of Patients with Graves’ Disease and Its Si
皮肌炎可累及心脏 ,主要改变有各种心律失常、充血性心衰、ＳＴ -Ｔ改变。心脏受累是皮肌炎死亡最常见并发症之一 ,应引起警惕。现报告 1例皮肌炎引起巨大倒置Ｔ波者。患者女 ,5 8岁
唐都医院瞄准国际前沿新技术 ,千方百计筹措资金 ,从国外引进治疗重症肌无力的新设备新技术 ,为患者带来福音 .重症肌无力是典型的严重危害患者身心健康的常见自身免疫性疾病
ＨＬＡ－ＤＱβ链第５７位的非门冬氨酸（ＮＡ）或门冬氨酸（Ａ）与１型糖尿病的易感性有关。国内外已有广泛报道，这些基因紧密连锁，使各单倍型由亲代完整传递到子代１。现已明确，糖尿病（ＤＭ）家族成员发生糖尿病者远
“到此已非尘世客,过来便是桃源人。”借用古人诗句来喻从桃源洞归来的感受,是再确切不过了。桃源洞国家森林公园（国家自然保护区）地处罗霄山脉中段,我国中亚热带南北过渡的交
有消化不良症状糖尿病患者胃肌电活动和胃排空的研究
Study on gastric myoelectrical activity and gastric emptying in patients with dyspeptic symptoms of
经济管理学院是2000年在原经济管理系的基础上组建而成的,现有会计学、工商管理、国际贸易、信息管理等四个系以及经济管理实验中心、能源经济研究中心,有会计学、市场营销、
The aggregation behavior of cyclic rod-coil(RC) diblock copolymers in dilute solutions is investigated through dissipative particle dynamics simulation. By vary
Two naphthalene(NP) and bipyridinium(BIPY~(2+)) alternately incorporated polymers P1 and P2 have been prepared through the formation of dynamic hydrazone bonds.