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抗生素后效应 (ＰＡＥ)系指细菌与抗生素短暂接触 ,当药物清除后 ,细菌生长仍然受到持续抑制的效应 ,这是抗生素对其作用靶细菌特有的效应。近年来 ,国外对ＰＡＥ这一新理论进行了深入研究 ,并将ＰＡＥ作为评价新抗生素药效动力学的重要参数。ＰＡＥ理论可为临床设计更为合理的
After antibiotic effect (PAE) refers to the brief contact of bacteria and antibiotics, when the drug is cleared, bacterial growth is still sustained inhibition of the effect, which is the role of antibiotics on its specific target bacteria effect. In recent years, the new theory of PAE abroad has been studied in depth, and PAE as an important parameter to evaluate pharmacodynamics of new antibiotics. PAE theory can be more rational for clinical design