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目的观察多种油脂肪乳(SMOF)营养治疗对有营养风险的胰腺癌患者免疫功能及炎性介质等方面的影响。方法选取有营养风险的胰腺癌患者60例,随机分为研究组和对照组。研究组给予SMOF营养治疗,对照组给予中长链脂肪乳营养治疗。分别测定营养治疗前和营养治疗后第3、7天CD4~+、CD8~+、CD4~+/CD8~+等免疫功能指标及CRP炎性介质水平指标。结果经过不同脂肪乳的营养治疗,在营养治疗后第7天研究组CD4~+、CD4~+/CD8~+较对照组高,CD8~+、CRP较对照组低,差异有统计学意义(P<0.05);研究组在营养支持后第7天时,CD4~+、CD4~+/CD8~+较营养治疗前升高,CD8~+、CRP较营养治疗前降低,差异有统计学意义(P<0.05)。结论SMOF营养治疗可改善有营养风险的胰腺癌患者免疫功能,抑制炎性介质的释放。
Objective To observe the effects of multiple lipid emulsion (SMOF) nutrition therapy on immune function and inflammatory mediators in patients with nutritional risk of pancreatic cancer. Methods Sixty patients with nutritional risk of pancreatic cancer were randomly divided into study group and control group. The study group was given SMOF nutrition treatment, while the control group was given medium-long-chain fatty emulsion nutrition treatment. The immune function indexes such as CD4 ~ +, CD8 ~ +, CD4 ~ + / CD8 ~ + and CRP inflammatory mediators before and after nutrition therapy were measured respectively. Results After the nutrition treatment with different fat milk, the CD4 +, CD4 + / CD8 + of the study group were higher than the control group on the 7th day after nutrition treatment, and the levels of CD8 + and CRP were lower than the control group (P <0.05). At the 7th day after nutritional support, the levels of CD4 ~ + and CD4 ~ + / CD8 ~ + in the study group were higher than those before nutrition treatment, while the levels of CD8 ~ + and CRP in the study group were lower than those before the nutrition treatment P <0.05). Conclusion SMOF nutrition therapy can improve the immune function of pancreatic cancer patients with nutritional risk and inhibit the release of inflammatory mediators.