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目的:观察环氧合酶-2(COX-2)与重症肝炎的关系。方法:ELISA法检测75例乙肝相关性重症肝炎患者和30例普通乙肝相关性肝病患者血清中COX-2相关前列腺素(PGs)代谢产物血栓素(TXB2)、6-酮-前列腺素F1α(6-keto-PGF1α)的水平。结果:各组重症肝炎患者血清TXB2和6-ke-to-PGF1α的水平均明显高于普通肝病患者(急性重症肝炎vs正常对照,P<0.01;亚急性重症肝炎:正常对照,P<0.01;慢性重症肝炎:正常对照,P<0.01)。随着病情的转归,TXB2/6-keto-PGF1α比值明显下降。结论:TXB2、6-keto-PGF1α的水平和TXB2/6-keto-PGF1α比值对揭示肝病发生重症肝炎的发展过程有一定的实用价值,对监测病情转归和预后有重要临床意义。
Objective: To observe the relationship between cyclooxygenase-2 (COX-2) and severe hepatitis. Methods: The levels of TXB2, 6-keto-PGF1α (6-keto-prostaglandin F1α) in COX-2-related prostaglandins (PGs) were detected by ELISA in 75 cases of hepatitis B patients with severe hepatitis B and 30 cases of common hepatitis B- -keto-PGF1α) levels. Results: The levels of serum TXB2 and 6-ke-to-PGF1α in patients with severe hepatitis were significantly higher than those in patients with common liver disease (acute severe hepatitis vs normal control, P <0.01; subacute severe hepatitis: normal control, P <0.01; Chronic severe hepatitis: normal control, P <0.01). With the prognosis of the disease, TXB2 / 6-keto-PGF1α ratio decreased significantly. CONCLUSION: The level of TXB2, 6-keto-PGF1α and the ratio of TXB2 / 6-keto-PGF1α have certain practical value in revealing the development of severe hepatitis in liver disease, and have important clinical value in monitoring the prognosis and prognosis.