论文部分内容阅读
目的 分析前列腺癌放射治疗的疗效及预后因素。方法 回顾分析本院常规放射治疗前列腺癌 4 5例 ,4 1例放射治疗前接受双侧睾丸切除 ,2 9例同时服用内分泌治疗药物。采用常规放射治疗技术 ,5次 /周 ,1.8～ 2 .0Gy/次 ,肿瘤剂量最低 5 0 .4Gy ,最高 75 .9Gy ,中位 6 8.3Gy。结果 中位随访 2 8个月 (范围 1～ 111个月 ) ,随访率 91.1%。 5年总生存率为 76 .4 % ,肿瘤特异生存率为 76 .5 %。1、2、3级急性胃肠道反应发生率分别为 5 3.5 %、7.0 %、9.3% ,1、2级急性泌尿生殖系统反应发生率分别为 4 1.9%、4 .7% ;1、2级胃肠道晚期反应发生率分别为 16 .7%、7.1% ,1、2、3级泌尿生殖系统晚期反应发生率分别为 2 3.8%、4 .8%、2 .4 %。结论 前列腺癌的放射治疗结果较为满意 ,治疗的副反应尚能承受
Objective To analyze the efficacy and prognostic factors of radiation therapy for prostate cancer. Methods The retrospective analysis of routine radiotherapy in our hospital, 45 cases of prostate cancer, 41 cases of bilateral orchiectomy before radiotherapy, 29 cases also take endocrine therapy. Using conventional radiotherapy techniques, 5 times / week, 1.8 ~ 2.0Gy / times, the lowest tumor dose of 50.4Gy, the highest 75.9Gy, the median 6 8.3Gy. Results The median follow-up was 28 months (range, 1 to 111 months) with a follow-up rate of 91.1%. The overall 5-year survival rate was 76.4% and the tumor-specific survival rate was 76.5%. The incidences of acute and / or genitourinary reactions in grades 1, 2 and 3 were 3.5%, 7.0% and 9.3% respectively, and the rates of acute urogenital reactions in grades 1 and 2 were 4 1.9% and 4.7%, respectively The rates of late gastrointestinal gastrointestinal reactions were 16.7% and 7.1% respectively. The incidences of late reactions of the genitourinary system were 23.8%, 4.8% and 2.4% respectively. Conclusion The result of radiotherapy of prostate cancer is satisfactory, and the side effects of treatment are still able to bear