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目的:探讨纳洛酮联合醒脑静、还原性谷胱甘肽注射液治疗急性酒精中毒的疗效及安全性评价。方法:97例患者随机分成2组,对照组(48例)使用纳洛酮治疗,治疗组(49例)在纳洛酮基础上联合醒脑静、还原性谷胱甘肽注射液治疗,同时监测生命体征及补液利尿、保护胃黏膜治疗。观察2组患者治疗的显效时间及症状消失时间,同时观察不良反应及并发症。结果:治疗组和对照组相比,显效时间及症状消失时间分别为(51.9±18.7)和(70.1±24.6)min、(94.3±38.6)和(143.1±43.6)min,在轻症酒精中毒患者中,治疗组显效时间短于对照组,差异无显著性,但症状消失时间明显短于对照组;在中、重症急性酒精中毒患者,不管显效时间还是症状消失时间,差异均具显著性。结论:纳洛酮联合醒脑静、还原性谷胱甘肽注射液治疗急性酒精中毒尤其是中、重度急性酒精中毒患者比单用纳洛酮组疗效更佳,不良反应少。
Objective: To evaluate the efficacy and safety of naloxone combined with xingnaojing and glutathione injection in the treatment of acute alcoholism. Methods: Ninety-seven patients were randomly divided into two groups. The control group (n = 48) was treated with naloxone. The treatment group (n = 49) was treated with naloxone combined with xingnaojing and reducing glutathione Monitoring vital signs and rehydration diuretic, gastric mucosal protection treatment. Two groups of patients were observed markedly effective time and symptoms disappear time, while observing adverse reactions and complications. Results: Compared with the control group, the effective time and symptom disappearance time were (51.9 ± 18.7) and (70.1 ± 24.6) min, (94.3 ± 38.6) and (143.1 ± 43.6) min respectively in the treatment group and the control group. , The treatment group markedly shorter effective time than the control group, the difference was not significant, but the symptoms disappear significantly shorter than the control group; in patients with severe acute alcoholism, regardless of the effective time or symptoms disappear time, the differences were significant. Conclusion: Naloxone combined with xingnaojing and reducing glutathione injection in the treatment of acute alcoholism, especially in patients with moderate and severe acute alcoholism, is better than naloxone alone and has fewer adverse reactions.